Zdorovʹe Rebenka (Apr 2019)

The relationship between the state of acid-forming function of the stomach and H.pylori invasion in gastroduodenitis in children

  • T.N. Mikhiеieva,
  • D.Yu. Nechytailo

DOI
https://doi.org/10.22141/2224-0551.14.0.2019.165520
Journal volume & issue
Vol. 14, no. 0
pp. 53 – 57

Abstract

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Background. Chronic gastroduodenitis occurs due to prolonged effects of endogenous and exogenous causes on the body. In the regulation of the acid-forming activity of parietal cells, both stimulating and suppressing mechanisms are involved. An increase in the gastrin secretion in the antrum may also occur as a result of H.pylori infection. The purpose of the study was to assess the relationship between the state of acid-forming function of the stomach and H.pylori invasion in children with chronic gastroduodenitis. Materials and methods. Sixty children of school age with a diagnosis of chronic uncomplicated gastroduodenal pathology were examined. An endoscopic examination of the upper digestive tract has been carried out in all children to determine the acid-forming and secretory function of the stomach. The diagnosis of H.pylori infection in children was carried out by enzyme-linked immunosorbent assay. Statistical processing of the data was performed using Microsoft Office Excel and Statistica 6.1. Results. The level of acid-forming and secretory function in the examined children was as followed: reduced — in 9 patients, preserved — in 29, elevated — in 12, undetermined — in 10 children with erosive gastroduodenitis. When establishing the presence of H.pylori by enzyme-linked immunosorbent assay, 28 (46.7 %) children had low antibody titer, 14 (23.3 %) — average, and 18 (30.0 %) had high titer. Patients with chronic erosive and hypertrophic gastroduodenitis showed a higher percentage of lesions of the gastric and duodenal mucosa due to H.pylori than patients with chronic superficial gastroduodenitis, both in endoscopic and serological study. Conclusions. In the examined children, a clear relationship was established between the state of the acid-forming and secretory function of the stomach and H.pylori invasion that depends on the degree of organic lesions of the mucous membrane in them.

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