Global Pediatric Health (Jan 2018)

Infant Feeding Regimens and Gastrointestinal Tolerance: A Multicenter, Prospective, Observational Cohort Study in China

  • Meng Mao MD,
  • Lan Zhang MD,
  • John Ge MD,
  • Jian Yan PhD,
  • Robert Northington PhD,
  • Manjiang Yao MD, PhD,
  • Joyce Nowacki MS, RD,
  • Nicholas P. Hays PhD

DOI
https://doi.org/10.1177/2333794X17750271
Journal volume & issue
Vol. 5

Abstract

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To study feeding tolerance in infants fed formula with increased sn -2 palmitate and oligofructose ( sn -2+OF) in a real-world setting, healthy Chinese infants were enrolled in this 48-day observational study on their current feeding regimens: exclusively breastfed (BF; n = 147), exclusively sn -2+OF formula-fed (FF; n = 150), or mixed-fed with breast milk and sn -2+OF formula (MF; n = 163). Throughout the study, incidence (90% confidence interval) of hard stools was ≤2.1% (0.0-5.3) in FF and 0.8% (0.0-3.5) in MF, with no hard stools in BF. Incidence of watery stools was ≤5.0% (1.0-9.2) in FF and ≥5.1% (2.4-9.3) in MF and BF. Gastrointestinal tolerance scores, although low in all groups (lower scores indicating better tolerance), were slightly higher ( P ≥ .03) in FF (17.5 ± 4.8) and MF (18.2 ± 5.0) versus BF (16.3 ± 3.2) at mid-study; this difference disappeared at study end. Overall, low incidences of hard and watery stools and good feeding tolerance were observed in infants fed sn -2+OF formula.