Prognostic value of preoperative neutrophil-to-lymphocyte ratio for prediction of severe cholecystitis

Abstract

Background: The predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with cholecystitis has not been established. The aim of this study was to investigate preoperative NLR in patients with cholecystitis and to identify a relevant NLR value that discriminates between simple and severe cholecystitis. Methods: This study included 136 patients who underwent laparoscopic cholecystectomy due to cholecystitis. The Receiver Operating Characteristic (ROC) analysis was performed to identify the most useful NLR cut-off value in relation to the severity of cholecystitis. The patients were divided into two groups according to the cut-off NLR value: high NLR group (> 4.18, n = 23) and low NLR group ( 4.18 was significantly associated with severe cholecystitis. The preoperative NLR in patients undergoing cholecystectomy due to cholecystitis could be a useful surrogate marker of severe cholecystitis.

Keywords

• cholecystitis
• inflammatory biomarkers
• neutrophil-to-lymphocyte ratio
• prognosis