Antimicrobial resistance of nosocomial Staphylococcus aureus isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014

Abstract

The study included 418 of the 841 clinical isolates of S. aureus, which were regarded as nosocomial. These 418 clinical nosocomial S. aureus strains were isolated in 2013-2014 from patients hospitalized in 25 hospitals in 19 Russian cities. Methicillin-resistance rate was 24.9% (n=104). Antimicrobials with the highest activity with no resistance detected were vancomycin, linezolid, cefilavancin, telavancin, daptomycine, tigecycline and fusidic acid. Other highly in-vitro active antimicrobials were trimethoprim-sulfamethoxazole, mupirocin and ceftaroline (0.5%, 2.2% and 4.3% non-susceptible isolates respectively). MRSA isolates were substantially less susceptible compare with MSSA to gentamicin (1.3% vs. 83.7%), clindamycin (1.6% vs. 40.4%), rifampicin (2.2% vs. 27.9%), tetracycline (12.1% vs. 35.6%), chloramphenicol (9.9% vs. 71.2%), ceftaroline (0% vs. 17.3%), ciprofloxacin (6.1% vs. 89.4%), and erythromycin (18.5% vs. 58.7%).

Keywords

• staphylococcus aureus
• antimicrobial resistance
• nosocomial infections
• mrsa