PROGNOSTIC VALUE OF ENDOTHELIAL DYSFUNCTION IN CORONARY AND BRACHIAL ARTERIES, AND COMMON RISK FACTORS IN DEVELOPMENT OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH MICROVASCULAR ANGINA

Abstract

Aim. To study prognostical significance of vasomotor disorder of coronary and brachial arteries, and traditional risk factors in development of cardiovascular complications in patients with microvascular angina (MVA) and cardial syndrome X; a retrospective 12-year observation.Material and methods. Totally, 41 patient included, with MVA (40 females/1 male), mean age at the moment of inclusion 43±4,1 y.o., 15% smokers). Endotheliumdependent vasodilation (EDV) of coronary arteries was assessed via intracoronary acetylcholine load, EDV of brachial artery — via high-resolution ultrasound in active hyperemia test.Results. It was found that in brachial EDV <4,7% group the risk of cardiovascular complications (p<0,05) is higher for 9-18 years of observation. Baseline EDV of coronary arteries in the study did not influence survival rate in MVA patients.Conclusion. Significant influence on cardiovascular events occurring in long-term follow-up of MVA patients, had the risk factors as smoking and brachial artery endothelial dysfunction.

Keywords

• microvascular angina prognosis
• endothelial dysfunction
• endotheliumdependent vasodilation
• acetylcholine test