Pyrinap ligands for enantioselective syntheses of amines

Qi Liu; Haibo Xu; Yuling Li; Yuan Yao; Xue Zhang; Yinlong Guo; Shengming Ma

doi:10.1038/s41467-020-20205-0

Nature Communications (Jan 2021)

Pyrinap ligands for enantioselective syntheses of amines

Qi Liu,
Haibo Xu,
Yuling Li,
Yuan Yao,
Xue Zhang,
Yinlong Guo,
Shengming Ma

Affiliations

Qi Liu: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Haibo Xu: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yuling Li: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yuan Yao: Research Center for Molecular Recognition and Synthesis, Department of Chemistry, Fudan University
Xue Zhang: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yinlong Guo: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Shengming Ma: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-20205-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Chiral amines find use as chiral ligands, resolving reagents and versatile building blocks as well as in pharmaceuticals and agrochemicals. Here, the authors developed Pyrinap ligands for the copper-catalyzed enantioselective A3-coupling of terminal alkynes, aldehydes, and amines affording optically active propargylic amines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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