Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

Lisha Li; Lisha Li; Lisha Li; Jiaye Lu; Jiaye Lu; Jiaye Lu; Jun Liu; Jun Liu; Junchao Wu; Junchao Wu; Junchao Wu; Xinyue Zhang; Xinyue Zhang; Yu Meng; Yu Meng; Xiying Wu; Xiying Wu; Zongguang Tai; Zongguang Tai; Quangang Zhu; Quangang Zhu; Quangang Zhu; Zhongjian Chen; Zhongjian Chen; Zhongjian Chen

doi:10.3389/fimmu.2023.1340677

Frontiers in Immunology (Jan 2024)

Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

Lisha Li,
Lisha Li,
Lisha Li,
Jiaye Lu,
Jiaye Lu,
Jiaye Lu,
Jun Liu,
Jun Liu,
Junchao Wu,
Junchao Wu,
Junchao Wu,
Xinyue Zhang,
Xinyue Zhang,
Yu Meng,
Yu Meng,
Xiying Wu,
Xiying Wu,
Zongguang Tai,
Zongguang Tai,
Quangang Zhu,
Quangang Zhu,
Quangang Zhu,
Zhongjian Chen,
Zhongjian Chen,
Zhongjian Chen

Affiliations

Lisha Li: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Lisha Li: Shanghai University, School of Medicine, Shanghai, China
Lisha Li: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Jiaye Lu: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Jiaye Lu: Shanghai University, School of Medicine, Shanghai, China
Jiaye Lu: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Jun Liu: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Jun Liu: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Junchao Wu: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Junchao Wu: Shanghai University, School of Medicine, Shanghai, China
Junchao Wu: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Xinyue Zhang: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Xinyue Zhang: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Yu Meng: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Yu Meng: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Xiying Wu: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Xiying Wu: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Zongguang Tai: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Zongguang Tai: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Quangang Zhu: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Quangang Zhu: Shanghai University, School of Medicine, Shanghai, China
Quangang Zhu: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China
Zhongjian Chen: Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
Zhongjian Chen: Shanghai University, School of Medicine, Shanghai, China
Zhongjian Chen: Shanghai Engineering Research Center of External Chinese Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fimmu.2023.1340677
Journal volume & issue: Vol. 14

Abstract

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Psoriasis is a chronic autoimmune inflammatory disease characterized by erroneous metabolism of keratinocytes. The development of psoriasis is closely related to abnormal activation and disorders of the immune system. Dysregulated skin protective mechanisms can activate inflammatory pathways within the epithelial immune microenvironment (EIME), leading to the development of autoimmune-related and inflammatory skin diseases. In this review, we initially emphasized the pathogenesis of psoriasis, paying particular attention to the interactions between the abnormal activation of immune cells and the production of cytokines in psoriasis. Subsequently, we delved into the significance of the interactions between EIME and immune cells in the emergence of psoriasis. A thorough understanding of these immune processes is crucial to the development of targeted therapies for psoriasis. Finally, we discussed the potential novel targeted therapies aimed at modulating the EIME in psoriasis. This comprehensive examination sheds light on the intricate underlying immune mechanisms and provides insights into potential therapeutic avenues of immune-mediated inflammatory diseases.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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