PLoS ONE (Jan 2021)

Impact of sex on use of low tidal volume ventilation in invasively ventilated ICU patients-A mediation analysis using two observational cohorts.

  • Pien Swart,
  • Rodrigo Octavio Deliberato,
  • Alistair E W Johnson,
  • Tom J Pollard,
  • Lucas Bulgarelli,
  • Paolo Pelosi,
  • Marcelo Gama de Abreu,
  • Marcus J Schultz,
  • Ary Serpa Neto

DOI
https://doi.org/10.1371/journal.pone.0253933
Journal volume & issue
Vol. 16, no. 7
p. e0253933

Abstract

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BackgroundStudies in patients receiving invasive ventilation show important differences in use of low tidal volume (VT) ventilation (LTVV) between females and males. The aims of this study were to describe temporal changes in VT and to determine what factors drive the sex difference in use of LTVV.Methods and findingsThis is a posthoc analysis of 2 large longitudinal projects in 59 ICUs in the United States, the 'Medical information Mart for Intensive Care III' (MIMIC III) and the 'eICU Collaborative Research DataBase'. The proportion of patients under LTVV (median VT ConclusionsWhile LTVV is increasingly used in females and males, females continue to receive LTVV less often than males. The sex difference is mainly driven by patients' body height and actual body weight, and not necessarily by sex. Use of LTVV in females could improve by paying more attention to a correct calculation of VT, i.e., using the correct body height.