Non-invasive fetal RHD determination in out-patient practice
S M Makhmudova,
S V Pavlovich,
D Iu Trofimov,
A E Donnikov,
L Z Faizulin,
A A D'iakonova,
V N Karnaukhov
Affiliations
S M Makhmudova
V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation; City clinical hospital №195 of the Department of Health of Moscow
S V Pavlovich
V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
D Iu Trofimov
V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
A E Donnikov
V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
L Z Faizulin
V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
A A D'iakonova
V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
V N Karnaukhov
V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
The aim of the study was to improve approaches to the use of Rh0(D) immune globulin in pregnant women with Rh-negative blood by introducing noninvasive method of determination of fetal rhesus blood factor by mother’s blood into curation program of pregnancy at risk of RBC sensitization. The accuracy of noninvasive method of rhesus genotyping in 204 pregnant women with Rh negative blood in 14-27 weeks of pregnancy was 99.0%. The determination of fetal rhesus allows personify implementation of immunological prophylaxis in Rh negative pregnant women.
