Nature Communications (Jul 2021)
Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery
- Dashuai Zhu,
- Jingli Hou,
- Meng Qian,
- Dawei Jin,
- Tian Hao,
- Yanjun Pan,
- He Wang,
- Shuting Wu,
- Shuo Liu,
- Fei Wang,
- Lanping Wu,
- Yumin Zhong,
- Zhilu Yang,
- Yongzhe Che,
- Jie Shen,
- Deling Kong,
- Meng Yin,
- Qiang Zhao
Affiliations
- Dashuai Zhu
- State key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University
- Jingli Hou
- Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University
- Meng Qian
- State key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University
- Dawei Jin
- Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
- Tian Hao
- State key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University
- Yanjun Pan
- Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
- He Wang
- State key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University
- Shuting Wu
- Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
- Shuo Liu
- School of Medicine, Nankai University
- Fei Wang
- State key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University
- Lanping Wu
- Department of Cardiac Ultrasound, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
- Yumin Zhong
- Diagnostic Imaging Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
- Zhilu Yang
- Key Laboratory of Advanced Technology for Materials of Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University
- Yongzhe Che
- School of Medicine, Nankai University
- Jie Shen
- College of Pharmacy, Nankai University
- Deling Kong
- State key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University
- Meng Yin
- Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
- Qiang Zhao
- State key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University
- DOI
- https://doi.org/10.1038/s41467-021-24804-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Nitric oxide (NO) is an important gaseous signaling molecule with multiple physiological roles in cardiovascular system. Here the authors develop a cardiac patch with NO releasing function that favors heart repair after myocardial infarction.
