Haematologica (Apr 2019)
Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors
- Michael A. Pulsipher,
- Brent R. Logan,
- Deidre M. Kiefer,
- Pintip Chitphakdithai,
- Marcie L. Riches,
- J. Douglas Rizzo,
- Paolo Anderlini,
- O’Susan F. Leitman,
- Hati Kobusingye,
- RaeAnne M. Besser,
- John P. Miller,
- Rebecca J. Drexler,
- Aly Abdel-Mageed,
- Ibrahim A. Ahmed,
- Luke P. Akard,
- Andrew S. Artz,
- Edward D. Ball,
- Ruthee-Lu Bayer,
- Carolyn Bigelow,
- Brian J. Bolwell,
- E. Randolph Broun,
- David C. Delgado,
- Katharine Duckworth,
- Christopher C. Dvorak,
- Theresa E. Hahn,
- Ann E. Haight,
- Parameswaran N. Hari,
- Brandon M. Hayes-Lattin,
- David A. Jacobsohn,
- Ann A. Jakubowski,
- Kimberly A. Kasow,
- Hillard M. Lazarus,
- Jane L. Liesveld,
- Michael Linenberger,
- Mark R. Litzow,
- Walter Longo,
- Margarida Magalhaes-Silverman,
- John M. McCarty,
- Joseph P. McGuirk,
- Shahram Mori,
- Vinod Parameswaran,
- Vinod K. Prasad,
- Scott D. Rowley,
- Witold B. Rybka,
- Indira Sahdev,
- Jeffrey R. Schriber,
- George B. Selby,
- Paul J. Shaughnessy,
- Shalini Shenoy,
- Thomas Spitzer,
- William T. Tse,
- Joseph P. Uberti,
- Madhuri Vusirikala,
- Edmund K. Waller,
- Daniel J. Weisdorf,
- Gregory A. Yanik,
- Willis H. Navarro,
- Mary M. Horowitz,
- Galen E. Switzer,
- Dennis L. Confer,
- Bronwen E. Shaw
Affiliations
- Michael A. Pulsipher
- Children’s Hospital Los Angeles, CA
- Brent R. Logan
- Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
- Deidre M. Kiefer
- Center for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN
- Pintip Chitphakdithai
- Center for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN
- Marcie L. Riches
- University of North Carolina Hospitals, Division of Hematology and Oncology Chapel Hill, NC
- J. Douglas Rizzo
- Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
- Paolo Anderlini
- Department of Stem Cell Transplantation and Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, TX
- O’Susan F. Leitman
- Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD
- Hati Kobusingye
- Center for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN
- RaeAnne M. Besser
- Center for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN
- John P. Miller
- National Marrow Donor Program/Be The Match, Minneapolis, MN
- Rebecca J. Drexler
- Center for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN
- Aly Abdel-Mageed
- Department of Pediatrics and Human Development, Helen DeVos Children’s Hospital, Grand Rapids, MI
- Ibrahim A. Ahmed
- Department of Hematology and Oncology, Children’s Mercy Hospitals and Clinics, Kansas City, MO
- Luke P. Akard
- Indiana Blood and Marrow Transplantation, Indianapolis, IN
- Andrew S. Artz
- University of Chicago Hospitals, IL
- Edward D. Ball
- University of California, San Diego Medical Center, La Jolla, CA
- Ruthee-Lu Bayer
- North Shore University Hospital, Manhasset, NY
- Carolyn Bigelow
- University of Mississippi Medical Center, Jackson, MS
- Brian J. Bolwell
- Taussig Cancer Institute, Cleveland Clinic Foundation, OH
- E. Randolph Broun
- Jewish Hospital, Cincinnati, OH
- David C. Delgado
- Indiana University Hospital/Riley Hospital for Children, IN
- Katharine Duckworth
- Wake Forest University Baptist Medical Center, Winston-Salem, NC
- Christopher C. Dvorak
- Division of Pediatric Blood and Marrow Transplantation, University of California San Francisco Benioff Children’s Hospital, CA
- Theresa E. Hahn
- Roswell Park Cancer Institute, Buffalo, NY
- Ann E. Haight
- Aflac Cancer and Blood Disorders Center, Division of Hematology/Oncology-Bone Marrow Pediatric Hematology & Medical Oncology, Children’s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA
- Parameswaran N. Hari
- Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
- Brandon M. Hayes-Lattin
- Doernbecher Children’s Hospital, Oregon Health & Science University, Portland, OR
- David A. Jacobsohn
- Children’s National Medical Center, Washington DC
- Ann A. Jakubowski
- Memorial Sloan Kettering Cancer Center – Adult, New York, NY
- Kimberly A. Kasow
- Pediatric Hematology Oncology Program, Bone Marrow and Stem Cell Transplantation Program, University of North Carolina Healthcare, Chapel Hill, NC
- Hillard M. Lazarus
- Seidman Cancer Center-University Hospitals Cleveland Medical Center, OH
- Jane L. Liesveld
- Strong Memorial Hospital - University of Rochester Medical Center, NY
- Michael Linenberger
- Division of Hematology, Fred Hutchinson Cancer Research Center, Seattle, WA
- Mark R. Litzow
- Division of Hematology, Mayo Clinic Rochester, MN
- Walter Longo
- University of Wisconsin Hospital and Clinics, Madison, WI
- Margarida Magalhaes-Silverman
- Blood and Marrow Transplant Program, University of Iowa Hospitals & Clinics, Iowa City, IA
- John M. McCarty
- Virginia Commonwealth University Massey Cancer Center Bone Marrow Transplant Program, Richmond, VA
- Joseph P. McGuirk
- University of Kansas, Westwood, KS
- Shahram Mori
- Florida Hospital Cancer Institute, Florida Center for Cellular Therapy, Orlando, FL
- Vinod Parameswaran
- Avera McKennan Transplant Institute, Sioux Falls, SD
- Vinod K. Prasad
- Duke Cancer Institute, Duke University Medical Center, Durham, NC
- Scott D. Rowley
- Hackensack University Medical Center, Washington DC
- Witold B. Rybka
- Penn State Health Milton S. Hershey Medical Center, PA
- Indira Sahdev
- Cohen Children’s Medical Center of New York, New Hyde Park, NY
- Jeffrey R. Schriber
- Cancer Transplant Institute Honor Health, Scottsdale, AZ
- George B. Selby
- HCA Health Services of Oklahoma, Inc., University of Oklahoma, Oklahoma City, OK
- Paul J. Shaughnessy
- Texas Transplant Institute, San Antonio, TX
- Shalini Shenoy
- Division of Hematology/Oncology, St. Louis Children’s Hospital, MO
- Thomas Spitzer
- Massachusetts General Hospital, Boston, MA
- William T. Tse
- Ann & Robert H. Lurie Children’s Hospital of Chicago, IL
- Joseph P. Uberti
- Karmanos Cancer Institute, Detroit, MI
- Madhuri Vusirikala
- Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX
- Edmund K. Waller
- Emory University Hospital, Atlanta, GA
- Daniel J. Weisdorf
- University of Minnesota Medical Center, Fairview, Minneapolis, MN
- Gregory A. Yanik
- The University of Michigan, Ann Arbor, MI
- Willis H. Navarro
- Center for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN
- Mary M. Horowitz
- Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
- Galen E. Switzer
- Division of General Internal Medicine, University of Pittsburgh, PA, USA
- Dennis L. Confer
- Center for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN;National Marrow Donor Program/Be The Match, Minneapolis, MN
- Bronwen E. Shaw
- Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
- DOI
- https://doi.org/10.3324/haematol.2018.200121
- Journal volume & issue
-
Vol. 104,
no. 4
Abstract
Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18–60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers in North America. Possible presence of medical comorbidities was verified prior to donation, and standardized pain and toxicity measures were assessed pre-donation, peri-donation, and one year following. Multivariate analyses showed similar experiences for BM collection in related and unrelated donors; however, related stem cell donors had increased risk of moderate [odds ratios (ORs) 1.42; P
