ImmunoTargets and Therapy (Mar 2024)

Efficacy and Safety Profile of Tuberculin Protein Purified Derivative Injection As Immunotherapy For the Treatment of Cutaneous and Anogenital Warts: A Review Article

  • Achdiat PA,
  • Suwarsa O,
  • Hidayat YM,
  • Shafiee MN,
  • Dwiyana RF,
  • Hindritiani R,
  • Sutedja E,
  • Pudjiati SR,
  • Hilmanto D,
  • Dhamayanti M,
  • Parwati I,
  • Maharani RH,
  • Sutedja EK,
  • Avriyanti E,
  • Yunitasari

Journal volume & issue
Vol. Volume 13
pp. 123 – 150

Abstract

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Pati Aji Achdiat,1,2 Oki Suwarsa,1,2 Yudi Mulyana Hidayat,2,3 Mohamad Nasir Shafiee,4 Reiva Farah Dwiyana,1,2 Reti Hindritiani,1 Endang Sutedja,1 Satiti Retno Pudjiati,5 Dany Hilmanto,2,6 Meita Dhamayanti,2,6 Ida Parwati,2,7 Retno Hesty Maharani,1 Eva Krishna Sutedja,1 Erda Avriyanti,1 Yunitasari1 1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Doctoral Study Program Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia; 3Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 4Department of Obstetrics and Gynecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 5Department of Dermatology and Venereology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; 6Department of Pediatric, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 7Department of Clinical Pathology, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, IndonesiaCorrespondence: Pati Aji Achdiat, Email [email protected]: Various treatments available today for anogenital and cutaneous warts have limitations, including time-consuming, challenging to perform, and the risk of scarring. A new treatment using tuberculin purified protein derivative (PPD) has been developed, which is expected to generate cellular immunity against HPV.Objective: To assess the evidence for the efficacy and safety of PPD treatment for cutaneous and anogenital warts.Materials and methods: A literature search was performed with the keyword-based search on digital libraries, including the National Library of Medicine, Cochrane Controlled Register of Trial, and Google Scholar, using the following terms: anogenital warts, condyloma acuminata, cutaneous warts, human papillomavirus, immunotherapy, and tuberculin purified protein derivative. Original studies on treating cutaneous or anogenital warts with PPD were included. The results were 47 clinical trials and 4 case reports. Most of the research was done in countries with common Mycobacterium tuberculosis infection. The treatment showed good efficacy. Comparative studies showed that the treatment has similar efficacy with other immunotherapies. No significant side effects were reported, with evidence of the safety use on the pregnant population.Conclusion: Based on good efficacy and safety, PPD can be considered an alternative therapy, especially in countries where tuberculosis is frequent.Keywords: anogenital warts, condyloma acuminata, cutaneous warts, human papillomavirus, immunotherapy, tuberculin purified protein derivative

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