BMB Reports (Sep 2013)

Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

  • Hyoseung Shin,
  • Hyeon Gyeong Yoo,
  • Shigeki Inui,
  • Satoshi Itami,
  • In Gyu Kim,
  • A-Ri Cho,
  • Dong Hun Lee,
  • Won Seok Park,
  • Ohsang Kwon,
  • Kwang Hyun Cho,
  • Chong Hyun Won

DOI
https://doi.org/10.5483/BMBRep.2013.46.9.228
Journal volume & issue
Vol. 46, no. 9
pp. 460 – 464

Abstract

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The progression of androgenetic alopecia is closely related toandrogen-inducible transforming growth factor (TGF)-β1 secretionby hair follicle dermal papilla cells (DPCs) in bald scalp.Physiological levels of androgen exposure were reported toincrease reactive oxygen species (ROS) generation. In thisstudy, rat vibrissae dermal papilla cells (DP-6) transfected withandrogen receptor showed increased ROS production followingandrogen treatment. We confirmed that TGF-β1 secretion isincreased by androgen treatment in DP-6, whereas androgeninducibleTGF-β1 was significantly suppressed by the ROSscavenger,N-acetyl cysteine. Therefore, we suggest that inductionof TGF-β1 by androgen is mediated by ROS in hair follicleDPCs. [BMB Reports 2013; 46(9): 460-464]

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