Therapeutic surfactant-stripped frozen micelles

Yumiao Zhang; Wentao Song; Jumin Geng; Upendra Chitgupi; Hande Unsal; Jasmin Federizon; Javid Rzayev; Dinesh K. Sukumaran; Paschalis Alexandridis; Jonathan F. Lovell

doi:10.1038/ncomms11649

Nature Communications (May 2016)

Therapeutic surfactant-stripped frozen micelles

Yumiao Zhang,
Wentao Song,
Jumin Geng,
Upendra Chitgupi,
Hande Unsal,
Jasmin Federizon,
Javid Rzayev,
Dinesh K. Sukumaran,
Paschalis Alexandridis,
Jonathan F. Lovell

Affiliations

Yumiao Zhang: Department of Biomedical Engineering, University at Buffalo, State University of New York
Wentao Song: Department of Biomedical Engineering, University at Buffalo, State University of New York
Jumin Geng: Department of Biomedical Engineering, University at Buffalo, State University of New York
Upendra Chitgupi: Department of Biomedical Engineering, University at Buffalo, State University of New York
Hande Unsal: Department of Chemistry; University at Buffalo, State University of New York
Jasmin Federizon: Department of Chemistry; University at Buffalo, State University of New York
Javid Rzayev: Department of Chemistry; University at Buffalo, State University of New York
Dinesh K. Sukumaran: Department of Chemistry; University at Buffalo, State University of New York
Paschalis Alexandridis: Department of Chemical and Biological Engineering, University at Buffalo, State University of New York
Jonathan F. Lovell: Department of Biomedical Engineering, University at Buffalo, State University of New York

DOI: https://doi.org/10.1038/ncomms11649
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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The excipients used to solubilise hydrophobic drugs sometimes interfere with drug behaviour or induce adverse side effects once injected. Here, the authors use a low-temperature process to obtain surfactant-stripped micelles with high drug concentration for delivery of a wide range of hydrophobic cargoes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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