Evaluation of curcumin-based ophthalmic nano-emulsion on atropine-induced dry eye in mice
Mahsa Hadipour Jahromy,
Mahnaz Qomi,
Simin Fazelipour,
Nafiseh Sami,
Farzaneh Faali,
Mehrnaz Karimi,
Farhad Adhami Moghadam
Affiliations
Mahsa Hadipour Jahromy
Herbal Pharmacology Research Center, School of Medicine, Dept of Pharmacology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding author. Dept of PharmacologyFaculty of Medicine, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, P.O. Box: 19168, Iran.
Mahnaz Qomi
Active Pharmaceutical Ingredients Research Center (APIRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Simin Fazelipour
School of Medicine, Dept of Histology & Anatomy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Nafiseh Sami
School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Farzaneh Faali
School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Mehrnaz Karimi
Department of Nanotechnology, School of Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Farhad Adhami Moghadam
School of Medicine, Dept of Ophthalmology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Background: One of the most efficient treatments for dry eye syndrome (DES) is to use nanocarriers as a potential delivery system. We aim to evaluate curcumin in a nano emulsion formulation. Methods: A new formulation containing 5.5% curcuminoid was used. DLS, Zeta potential, TEM, and HPLC tests were performed to determine the size and morphology. First, 30 mice were selected as atropine-induced dry eye models. Next, 25 mice in 5 groups were treated with the nano emulsion at different doses, and corneal tissues were separated for evaluation. Results: The DLS test results were indicative of the particles' stability. Nano curcumin appeared to be thoroughly effective in all groups, with the highest dose showing the most similarity to the healthy control group. Conclusions: Curcumin-based nano emulsion eye drop is a promising candidate for DES management. However, further investigation is required to evaluate the possible risks in humans.
