P7.04 PROGRESSIVE ARTERIAL STIFFENING IN RENAL TRANSPLANT RECIPIENTS – RESULTS OF 28-MONTH FOLLOW-UP

Abstract

Recent follow-up studies showed no change or even short-term improvement of arterial stiffness after kidney transplantation. Data from general population and end-stage renal disease patients suggest, that PWV increases with age of 0,07–0,08m/s for each year of life. It was shown recently that reduced glomerular filtration rate (GFR) is associated with increased arterial stiffness in RTR. We investigated the change of PWV during follow-up and its relationship with graft function. Carotid-femoral PWV was measured at baseline (PWV1) and after 28±3 (range 24–34) months of follow-up (PWV2) in 61 RTR aged 49±12 years. Fasting blood was collected for serum creatinine, calcium (Ca), phosphorus (P), and high-sensitive C-reactive protein (hsCRP). GFR was calculated with MDRD formula (eGFR). ΔPWV was calculated as (PWV2-PWV1)/PWV1. Clinical and laboratory data were analysed to identify factors associated with ΔPWV. Results are shown as mean±SD. Baseline Follow-up P PWV (m/s) 9,1±1,7 9,8±2,0 < 0,002 Body mass (kg) 73,7±13,9 75,4±13,6 < 0,001 SBP (mmHg) 132±17 137±19 =0,05 DBP (mmHg) 83±11 84±10 NS MAP (mmHg) 99±12 102±12 NS PP (mmHg) 50±11 53±14 <0,05 eGFR (ml/min/1,73m2) 55±16 56±16 NS Serum Ca, P, Ca × P product, hsCRP did not change during follow-up. Significant positive correlation was found between ΔPWV and serum phosphorus (r=0,27; p<0,05) and Ca × P product (r=0,25; p<0,05) but not with body mass, BMI, SBP, DBP, MAP, PP, Ca, eGFR, hsCRP. Arterial stiffness increased in renal transplant recipients despite stable graft function. Phosporus matebolism disturbances might be involved in arterial stiffening in RTR.