Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

Young-Kwon Park; Ji-Eun Lee; Zhijiang Yan; Kaitlin McKernan; Tommy O’Haren; Weidong Wang; Weiqun Peng; Kai Ge

doi:10.1038/s41467-021-21893-y

Nature Communications (Mar 2021)

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

Young-Kwon Park,
Ji-Eun Lee,
Zhijiang Yan,
Kaitlin McKernan,
Tommy O’Haren,
Weidong Wang,
Weiqun Peng,
Kai Ge

Affiliations

Young-Kwon Park: Adipocyte Biology and Gene Regulation Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH)
Ji-Eun Lee: Adipocyte Biology and Gene Regulation Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH)
Zhijiang Yan: Laboratory of Genetics and Genomics, National Institute on Aging, NIH
Kaitlin McKernan: Adipocyte Biology and Gene Regulation Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH)
Tommy O’Haren: Adipocyte Biology and Gene Regulation Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH)
Weidong Wang: Laboratory of Genetics and Genomics, National Institute on Aging, NIH
Weiqun Peng: Department of Physics, The George Washington University
Kai Ge: Adipocyte Biology and Gene Regulation Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH)

DOI: https://doi.org/10.1038/s41467-021-21893-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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The SWI/SNF complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) play critical roles in enhancer activation, however the interplay between them has remained unclear. Here the authors show that BAF and MLL4 are interdependent in promoting enhancer activation by lineage-determining transcription factors during adipogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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