New potential biomarkers for breast cancer (review of literature)

Abstract

Identification of markers that will identify the disease at an early preclinical stage, is the main goal of our research. Diagnostic marker should have the following characteristics: high sensitivity and specificity, be readily accessible for the analysis of tissues and body fluids, and above all, be determined in blood plasma. Early detection of breast cancer markers in the blood – a promising trend in science, however, is technically challenging because of the heterogeneity of the disease and the variability of blood plasma proteins. Our review is devoted to theoretical assumptions and practical results of the search of new proteomic markers of breast cancer.

Keywords

• breast cancer
• proteomics
• mass spectrometry
• cox-2 signaling pathway
• markers of metastatic breast cancer
• the target for targeted therapy