Molecular mechanism on forcible ejection of ATPase inhibitory factor 1 from mitochondrial ATP synthase

Ryohei Kobayashi; Hiroshi Ueno; Kei-ichi Okazaki; Hiroyuki Noji

doi:10.1038/s41467-023-37182-9

Nature Communications (Mar 2023)

Molecular mechanism on forcible ejection of ATPase inhibitory factor 1 from mitochondrial ATP synthase

Ryohei Kobayashi,
Hiroshi Ueno,
Kei-ichi Okazaki,
Hiroyuki Noji

Affiliations

Ryohei Kobayashi: Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo
Hiroshi Ueno: Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo
Kei-ichi Okazaki: Research Center for Computational Science, Institute for Molecular Science
Hiroyuki Noji: Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-023-37182-9
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

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IF1 is a natural inhibitor of mitochondrial FoF1-ATP synthase, which blocks catalysis and rotation of the F1 motor. Here, the authors show the rotational-direction-dependence of activation from IF1 inhibition, with IF1 being readily dissociated when F1 rotates to the clockwise direction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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