Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves

Abstract

The present study was undertaken to investigate the protective effect of hydroalcoholic extract of leaves of Ipomoea staphylina against carbon tertrachloride- and gentamicin-induce hepatotoxicity and nephrotoxicity in rats respectively. The extract (200 mg/kg, p.o) showed hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity by significantly (p<0.001) reducing the levels of AST, ALT, ALP, total bilirubin and significantly (p<0.001) increasing the serum total protein. The extract also showed nephro-protective activity against gentamicin-induced nephrotoxicity by significantly (p<0.001) reducing the levels of blood urea, blood urea nitrogen (BUN), serum creatinine and significantly (p<0.001) increasing the serum total protein. The extract also improves the histology of the liver and kidney. The total phenolic content and the total flavonoid content of the extract were 94.59 ± 2.54 mg gallic acid equivalent/g and 44.68 ± 2.00 mg rutin equivalent/g respectively.

Keywords

• Carbon tetrachloride
• Gentamicin
• Ipomoea staphylina
• Nephroprotective
• Nephrotoxicity