Scientific Reports (Jun 2022)
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study
- Ryohei Yamamoto,
- Enyu Imai,
- Shoichi Maruyama,
- Hitoshi Yokoyama,
- Hitoshi Sugiyama,
- Asami Takeda,
- Shunya Uchida,
- Tatsuo Tsukamoto,
- Kazuhiko Tsuruya,
- Yasuhiro Akai,
- Kosaku Nitta,
- Megumu Fukunaga,
- Hiroki Hayashi,
- Kosuke Masutani,
- Takashi Wada,
- Tsuneo Konta,
- Ritsuko Katafuchi,
- Saori Nishio,
- Shunsuke Goto,
- Hirofumi Tamai,
- Arimasa Shirasaki,
- Tatsuya Shoji,
- Kojiro Nagai,
- Tomoya Nishino,
- Kunihiro Yamagata,
- Junichiro J. Kazama,
- Keiju Hiromura,
- Hideo Yasuda,
- Makoto Mizutani,
- Tomohiko Naruse,
- Takeyuki Hiramatsu,
- Kunio Morozumi,
- Hiroshi Sobajima,
- Yosuke Saka,
- Eiji Ishimura,
- Daisuke Ichikawa,
- Takashi Shigematsu,
- Tadashi Sofue,
- Shouichi Fujimoto,
- Takafumi Ito,
- Hiroshi Sato,
- Ichiei Narita,
- Yoshitaka Isaka,
- JNSCS Investigators
Affiliations
- Ryohei Yamamoto
- Health and Counseling Center, Osaka University
- Enyu Imai
- Nakayamadera Imai Clinic
- Shoichi Maruyama
- Department of Nephrology, Nagoya University Graduate School of Medicine
- Hitoshi Yokoyama
- Department of Nephrology, Kanazawa Medical University School of Medicine
- Hitoshi Sugiyama
- Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
- Asami Takeda
- Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital
- Shunya Uchida
- Department of Internal Medicine, Teikyo University School of Medicine
- Tatsuo Tsukamoto
- Department of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute
- Kazuhiko Tsuruya
- Department of Nephrology, Nara Medical University
- Yasuhiro Akai
- First Department of Internal Medicine, Nara Medical University
- Kosaku Nitta
- Department of Nephrology, Tokyo Women’s Medical University
- Megumu Fukunaga
- Division of Nephrology, Department of Internal Medicine, Toyonaka Municipal Hospital
- Hiroki Hayashi
- Department of Nephrology, Fujita Health University School of Medicine
- Kosuke Masutani
- Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University
- Takashi Wada
- Department of Nephrology and Laboratory Medicine, Kanazawa University
- Tsuneo Konta
- Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
- Ritsuko Katafuchi
- Kidney Unit, National Hospital Organization Fukuokahigashi Medical Center
- Saori Nishio
- Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine
- Shunsuke Goto
- Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine
- Hirofumi Tamai
- Department of Nephrology, Anjo Kosei Hospital
- Arimasa Shirasaki
- Department of Nephrology, Ichinomiya Municipal Hospital
- Tatsuya Shoji
- Department of Kidney Disease and Hypertension, Osaka General Medical Center
- Kojiro Nagai
- Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
- Tomoya Nishino
- Department of Nephrology, Nagasaki University Hospital
- Kunihiro Yamagata
- Department of Nephrology, Faculty of Medicine, University of Tsukuba
- Junichiro J. Kazama
- Department of Nephrology and Hypertension, Fukushima Medical University School of Medicine
- Keiju Hiromura
- Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine
- Hideo Yasuda
- Internal Medicine 1, Hamamatsu University School of Medicine
- Makoto Mizutani
- Department of Nephrology, Handa City Hospital
- Tomohiko Naruse
- Department of Nephrology, Kasugai Municipal Hospital
- Takeyuki Hiramatsu
- Department of Nephrology, Konan Kosei Hospital
- Kunio Morozumi
- Department of Nephrology, Masuko Memorial Hospital
- Hiroshi Sobajima
- Department of Diabetology and Nephrology, Ogaki Municipal Hospital
- Yosuke Saka
- Department of Nephrology, Yokkaichi Municipal Hospital
- Eiji Ishimura
- Department of Nephrology, Osaka City University Graduate School of Medicine
- Daisuke Ichikawa
- Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine
- Takashi Shigematsu
- Department of Nephrology, Wakayama Medical University
- Tadashi Sofue
- Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University
- Shouichi Fujimoto
- Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki
- Takafumi Ito
- Division of Nephrology, Shimane University Hospital
- Hiroshi Sato
- Department of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine
- Ichiei Narita
- Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences
- Yoshitaka Isaka
- Department of Nephrology, Osaka University Graduate School of Medicine
- JNSCS Investigators
- DOI
- https://doi.org/10.1038/s41598-022-13067-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Abstract Previous studies reported conflicting results regarding an association between serum albumin concentration and the cumulative incidence of remission of proteinuria in adult patients with minimal change disease (MCD). The present study aimed to clarify the clinical impact of serum albumin concentration and the cumulative incidence of remission and relapse of proteinuria in 108 adult patients with MCD at 40 hospitals in Japan, who were enrolled in a 5-year prospective cohort study of primary nephrotic syndrome, the Japan Nephrotic Syndrome Cohort Study (JNSCS). The association between serum albumin concentration before initiation of immunosuppressive treatment (IST) and the cumulative incidence of remission and relapse were assessed using multivariable-adjusted Cox proportional hazards models. Remission defined as urinary protein 1.5 g/dL) showed significantly slow remission. In conclusion, lower serum albumin concentration and higher eGFR were associated with earlier remission in MCD, but not with relapse.
