Phospholipid bilayers in model membranes and drug delivery systems: from physics to pharmacy

Abstract

Lipids spontaneously aggregate in an aqueous environment forming supramolecular structures of various architectures known as liquid crystalline mesophases. Their thermodynamic properties determined by dual polar/apolar nature coupled with the possibility to modulate the structural parameters, phase geometry and stability are challenging for applications in drug delivery systems. We review a few examples of functionality of lipid bilayers.

Keywords

• lipid bilayer
• non-lamellar phases
• antimicrobial peptides
• lipoplexes
• pulmonary surfactant