Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

Yunmei Wang; Huiyun Gao; Can Shi; Paul W. Erhardt; Alexander Pavlovsky; Dmitry A. Soloviev; Kamila Bledzka; Valentin Ustinov; Liang Zhu; Jun Qin; Adam D. Munday; Jose Lopez; Edward Plow; Daniel I. Simon

doi:10.1038/ncomms15559

Nature Communications (May 2017)

Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

Yunmei Wang,
Huiyun Gao,
Can Shi,
Paul W. Erhardt,
Alexander Pavlovsky,
Dmitry A. Soloviev,
Kamila Bledzka,
Valentin Ustinov,
Liang Zhu,
Jun Qin,
Adam D. Munday,
Jose Lopez,
Edward Plow,
Daniel I. Simon

Affiliations

Yunmei Wang: Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine and Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center
Huiyun Gao: Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine and Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center
Can Shi: Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine and Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center
Paul W. Erhardt: Department of Medicinal and Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences
Alexander Pavlovsky: Department of Medicinal and Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences
Dmitry A. Soloviev: Department of Molecular Cardiology, Cleveland Clinic
Kamila Bledzka: Department of Molecular Cardiology, Cleveland Clinic
Valentin Ustinov: Department of Molecular Cardiology, Cleveland Clinic
Liang Zhu: Department of Molecular Cardiology, Cleveland Clinic
Jun Qin: Department of Molecular Cardiology, Cleveland Clinic
Adam D. Munday: Bloodworks Northwest Research Institute
Jose Lopez: Bloodworks Northwest Research Institute
Edward Plow: Department of Molecular Cardiology, Cleveland Clinic
Daniel I. Simon: Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine and Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center

DOI: https://doi.org/10.1038/ncomms15559
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which may provide clues for the development of new anti-thrombotic drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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