Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma

Abdolamir Allameh; Nico Hüttmann; Edouard Charlebois; Angeliki Katsarou; Wen Gu; Konstantinos Gkouvatsos; Elisa Pasini; Mamatha Bhat; Zoran Minic; Maxim Berezovski; Maria Guido; Carine Fillebeen; Kostas Pantopoulos

doi:10.1038/s42003-022-03108-2

Communications Biology (Feb 2022)

Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma

Abdolamir Allameh,
Nico Hüttmann,
Edouard Charlebois,
Angeliki Katsarou,
Wen Gu,
Konstantinos Gkouvatsos,
Elisa Pasini,
Mamatha Bhat,
Zoran Minic,
Maxim Berezovski,
Maria Guido,
Carine Fillebeen,
Kostas Pantopoulos

Affiliations

Abdolamir Allameh: Lady Davis Institute for Medical Research and Department of Medicine, McGill University
Nico Hüttmann: Department of Chemistry and Biomolecular Sciences, University of Ottawa
Edouard Charlebois: Lady Davis Institute for Medical Research and Department of Medicine, McGill University
Angeliki Katsarou: Lady Davis Institute for Medical Research and Department of Medicine, McGill University
Wen Gu: Lady Davis Institute for Medical Research and Department of Medicine, McGill University
Konstantinos Gkouvatsos: Lady Davis Institute for Medical Research and Department of Medicine, McGill University
Elisa Pasini: Ajmera Transplant Program, and Division of Gastroenterology and Hepatology, University Health Network
Mamatha Bhat: Ajmera Transplant Program, and Division of Gastroenterology and Hepatology, University Health Network
Zoran Minic: Department of Chemistry and Biomolecular Sciences, University of Ottawa
Maxim Berezovski: Department of Chemistry and Biomolecular Sciences, University of Ottawa
Maria Guido: Department of Medicine, University of Padova
Carine Fillebeen: Lady Davis Institute for Medical Research and Department of Medicine, McGill University
Kostas Pantopoulos: Lady Davis Institute for Medical Research and Department of Medicine, McGill University

DOI: https://doi.org/10.1038/s42003-022-03108-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

Hemojuvelin (HJV), a BMP co-receptor promoting hepcidin expression in the liver, has a hepatoprotective function and its deficiency in mice triggers mitochondrial dysfunction and hepatocarcinogenesis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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