Nature Communications (May 2018)

Structural basis for cofilin binding and actin filament disassembly

  • Kotaro Tanaka,
  • Shuichi Takeda,
  • Kaoru Mitsuoka,
  • Toshiro Oda,
  • Chieko Kimura-Sakiyama,
  • Yuichiro Maéda,
  • Akihiro Narita

DOI
https://doi.org/10.1038/s41467-018-04290-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

Cofilin is a small actin-binding protein that accelerates actin turnover by disassembling actin filaments. Here the authors present the 3.8 Å cryo-EM structure of a cofilin-decorated actin filament and discuss mechanistic implications.