Nature Communications (Mar 2023)
Non-canonical functions of SNAIL drive context-specific cancer progression
- Mariel C. Paul,
- Christian Schneeweis,
- Chiara Falcomatà,
- Chuan Shan,
- Daniel Rossmeisl,
- Stella Koutsouli,
- Christine Klement,
- Magdalena Zukowska,
- Sebastian A. Widholz,
- Moritz Jesinghaus,
- Konstanze K. Heuermann,
- Thomas Engleitner,
- Barbara Seidler,
- Katia Sleiman,
- Katja Steiger,
- Markus Tschurtschenthaler,
- Benjamin Walter,
- Sören A. Weidemann,
- Regina Pietsch,
- Angelika Schnieke,
- Roland M. Schmid,
- Maria S. Robles,
- Geoffroy Andrieux,
- Melanie Boerries,
- Roland Rad,
- Günter Schneider,
- Dieter Saur
Affiliations
- Mariel C. Paul
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Christian Schneeweis
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Chiara Falcomatà
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Chuan Shan
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Daniel Rossmeisl
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Stella Koutsouli
- Institute of Medical Psychology, Faculty of Medicine, LMU Munich
- Christine Klement
- Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich
- Magdalena Zukowska
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Sebastian A. Widholz
- Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich
- Moritz Jesinghaus
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Konstanze K. Heuermann
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Thomas Engleitner
- Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich
- Barbara Seidler
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Katia Sleiman
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Katja Steiger
- Institute of Pathology, Technische Universität München
- Markus Tschurtschenthaler
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Benjamin Walter
- Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München
- Sören A. Weidemann
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Regina Pietsch
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Angelika Schnieke
- Livestock Biotechnology, School of Life Sciences, Technische Universität München
- Roland M. Schmid
- Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München
- Maria S. Robles
- Institute of Medical Psychology, Faculty of Medicine, LMU Munich
- Geoffroy Andrieux
- Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
- Melanie Boerries
- Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
- Roland Rad
- Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich
- Günter Schneider
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- Dieter Saur
- Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK)
- DOI
- https://doi.org/10.1038/s41467-023-36505-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
SNAIL promotes tumour metastasis through inducing epithelial to mesenchymal transition (EMT). Here the authors report that SNAIL bypasses senescence and regulates cell cycle progression to promote pancreatic carcinogenesis and this is independent of EMT induction.
