Pruritus as a Presenting Symptom of FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia

Abstract

Mohammad Abu-Tineh,1 Esra’a Aljaloudi,2 Mohamed A Yassin1 1Department of Oncology- Hematology and BMT Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar; 2Department of Family Medicine, Hamad Medical Corporation, Doha, QatarCorrespondence: Mohammad Abu-TinehDepartment of Oncology- Hematology and BMT Section- National Center for Cancer Care and Research, Hamad Medical Corporation, Alrayan Street, Doha, QatarTel [phone]Email [email protected]: Eosinophilia can be found in a variety of benign and malignant conditions, and a persistent eosinophilic count of more than 1500/mm3 necessitates additional investigation. Patients with FIP1L1-PDGFRA-positive chronic eosinophilic leukemia might present as asymptomatic or in a catastrophic state with multi-organ involvement. We present the case of a young male patient who was diagnosed with FIP1L1-PDGFRA chronic eosinophilic leukemia after a long history of recurrent cutaneous symptoms with no systemic signs.Keywords: chronic eosinophilic leukemia, FIP1L1-PDGFRA, eosinophilia, imatinib

Keywords

• chronic eosinophilic leukemia
• fip1l1-pdgfra
• eosinophilia
• imatinib