Nature Communications (Oct 2021)

Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules

  • Hao Liu,
  • Jianqun Zheng,
  • Lei Zhu,
  • Lele Xie,
  • Yawen Chen,
  • Yirong Zhang,
  • Wei Zhang,
  • Yue Yin,
  • Chao Peng,
  • Jun Zhou,
  • Xueliang Zhu,
  • Xiumin Yan

DOI
https://doi.org/10.1038/s41467-021-26058-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Ciliary beating is mediated by the axonemal central pair microtubules, though how these non-centrosomal microtubules form is poorly understood. Here the authors show that a trio of proteins act cooperatively to initiate central microtubule formation in mammals.