Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy

Abstract

Objectives This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP). Methods Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated. Results Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529. Conclusion Serum miR-101 level may be a biomarker for grading HDCP.

Keywords

• mir-101
• gestational hypertension
• mild preeclampsia
• severe preeclampsia
• sflt-1
• receiver operating characteristic curve
• severity of illness
• biomarkers