Ukrainian Journal of Veterinary Sciences (Jul 2020)
INFLUENCE OF PHOSPHOLIPID-CONTAINING ADDITIVES ON THE FUNCTIONAL CONDITION OF ORGANS AND SYSTEMS OF MICE
Abstract
Numerous studies in experiments on laboratory animals and in clinical practice have confirmed the positive effect of essential phospholipids on the structural organization of cell membranes, intracellular metabolism, mitochondrial function, antioxidant processes, which explains the active use of phospholipid-containing drugs in hepato- and enteropathologies, cardiovascular diseases, etc. The raw material of animal origin, in particular milk, which is a safe source of biologically active substances, has a structural similarity with phospholipids of mammalian tissues. Based on them, a biologically active additive (BAA) "FLP-MD" was created, which is characterized by membranotropic properties and reparative effect. The aim of this work was to investigate the biological effect of the liposomal form of BAA "FLP-MD" based on milk phospholipids on the body of clinically healthy laboratory mice. Determination of the toxicity of phospholipid-containing BAA "FLP-MD" was performed on mice of the CBA line. The duration of the experiment was 16 days. The results of the studies indicate a probable increase in body weight of mice of the CBA line aŌer the 10th day of intragastric administration of 1% solution of liposomal form of BAA "FLP-MD". As a result of the study of biochemical parameters of plasma / native blood, the absence of toxic effects of the liposomal form of BAA "FLP-MD" on the functional state of the body of mice was set. Morphological parameters of peripheral blood in these animals did not change significantly. According to the results of microscopic studies, no negative effect of the liposomal form of BAA "FLP-MD" on the structure microstructure of the mucous membrane of the gastrointestinal tract was found. Therefore, the components of BAA "FLP-MD" do not adversely affect the functional state of organs and systems of laboratory mice and do not show a toxic effect, which allows it to be recommended for use in veterinary medicine as a means of rehabilitation therapy
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