Communications Biology (Aug 2022)

Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts

  • Agnieszka Brojakowska,
  • Anupreet Kour,
  • Mark Charles Thel,
  • Eunbee Park,
  • Malik Bisserier,
  • Venkata Naga Srikanth Garikipati,
  • Lahouaria Hadri,
  • Paul J. Mills,
  • Kenneth Walsh,
  • David A. Goukassian

DOI
https://doi.org/10.1038/s42003-022-03777-z
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 6

Abstract

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Deep targeted DNA sequencing of peripheral blood mononuclear cells isolated from blood samples from 14 astronauts who flew Shuttle missions between 1998–2001 identifies 34 non-silent mutations, predominantly in TP53 and DNMT3A.