Nature Communications (Apr 2021)
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
- Bing He,
- Ping Chen,
- Sonia Zambrano,
- Dina Dabaghie,
- Yizhou Hu,
- Katja Möller-Hackbarth,
- David Unnersjö-Jess,
- Gül Gizem Korkut,
- Emmanuelle Charrin,
- Marie Jeansson,
- Maria Bintanel-Morcillo,
- Anna Witasp,
- Lars Wennberg,
- Annika Wernerson,
- Bernhard Schermer,
- Thomas Benzing,
- Patrik Ernfors,
- Christer Betsholtz,
- Mark Lal,
- Rickard Sandberg,
- Jaakko Patrakka
Affiliations
- Bing He
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Ping Chen
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Sonia Zambrano
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Dina Dabaghie
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Yizhou Hu
- Division of Neuroscience, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institute
- Katja Möller-Hackbarth
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- David Unnersjö-Jess
- Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne
- Gül Gizem Korkut
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Emmanuelle Charrin
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Marie Jeansson
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Maria Bintanel-Morcillo
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Anna Witasp
- Division of Renal Medicine, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute
- Lars Wennberg
- Division of Transplantation, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute
- Annika Wernerson
- Division of Renal Medicine, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute
- Bernhard Schermer
- Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne
- Thomas Benzing
- Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne
- Patrik Ernfors
- Division of Neuroscience, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institute
- Christer Betsholtz
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- Mark Lal
- Bioscience, Cardiovascular, Renal and Metabolism, R&D Biopharmaceuticals
- Rickard Sandberg
- Department of Cell and Molecular Biology, Karolinska Institute
- Jaakko Patrakka
- Karolinska Institute/AstraZeneca Integrated Cardio Metabolic Center (ICMC)
- DOI
- https://doi.org/10.1038/s41467-021-22331-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and highlight differences between mouse and human cells.
