Frontiers in Natural Products (Sep 2023)
Twenty-five years of natural products research in NuBBE
- Helena Mannochio-Russo,
- Helena Mannochio-Russo,
- Ana Letícia Pires dos Santos,
- Paula Carolina Pires Bueno,
- Paula Carolina Pires Bueno,
- Rafael Vieira,
- Rafael Vieira,
- Meri Emili Ferreira Pinto,
- Suzana Aparecida Silva Queiroz,
- Luiz Antonio Dutra,
- Lidiane Gaspareto Felippe,
- Andrea Nastri de Luca Batista,
- Tatiana Maria de Souza-Moreira,
- Marilia Valli,
- Rebeca Previate Medina,
- Angela Regina Araujo,
- Alan Cesar Pilon,
- Ian Castro-Gamboa,
- Alberto José Cavalheiro,
- Dulce Helena Siqueira Silva,
- Maysa Furlan,
- Vanderlan da Silva Bolzani
Affiliations
- Helena Mannochio-Russo
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Helena Mannochio-Russo
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, United States
- Ana Letícia Pires dos Santos
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Paula Carolina Pires Bueno
- Institute of Chemistry, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil
- Paula Carolina Pires Bueno
- Leibniz Institute of Vegetable and Ornamental Crops (IGZ), Grossbeeren, Germany
- Rafael Vieira
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Rafael Vieira
- Federal Institute of Education, Science and Technology of Rondônia, Ji-Paraná, Rondônia, Brazil
- Meri Emili Ferreira Pinto
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Suzana Aparecida Silva Queiroz
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Luiz Antonio Dutra
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Lidiane Gaspareto Felippe
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Andrea Nastri de Luca Batista
- Department of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Niterói, Brazil
- Tatiana Maria de Souza-Moreira
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Marilia Valli
- Laboratory of Medicinal and Computational Chemistry (LQMC), Centre for Research and Innovation in Biodiversity and Drug Discovery (CIBFar), Institute of Physics of São Carlos, University of São Paulo (USP), São Carlos, SP, Brazil
- Rebeca Previate Medina
- Federal Institute of Education, Science and Technology of São Paulo, Cubatão, São Paulo, Brazil
- Angela Regina Araujo
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Alan Cesar Pilon
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Ian Castro-Gamboa
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Alberto José Cavalheiro
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Dulce Helena Siqueira Silva
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Maysa Furlan
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- Vanderlan da Silva Bolzani
- Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, Brazil
- DOI
- https://doi.org/10.3389/fntpr.2023.1252092
- Journal volume & issue
-
Vol. 2
Abstract
The richness of Brazilian biodiversity translates into a valuable collection of molecules with biological properties that range from ecological functions to pharmacological properties. For over 25 years, the Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE) has conducted extensive investigations into the chemical entities of numerous plant and microorganism species, resulting in the discovery of over a thousand natural compounds spanning various chemical classes (such as shikimate derivatives, phenylpropanoids, terpenoids, alkaloids, and peptides). The research goals within the natural products field encompass phytochemical studies, investigations of endophytic fungi and marine organisms, biosynthetic studies, medicinal chemistry, and the development of innovative methodologies. This comprehensive review article aims to offer valuable insights into the multifaceted research endeavors conducted in NuBBE. In this way, accomplishments, perspectives, and opportunities for advancing natural products research in Brazil are highlighted, seeking to inspire and motivate other research groups in the field of natural products–especially those located in emerging countries with rich biodiversity.
Keywords
