Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

Man Xu; Maria Fernanda Perdomo; Salla Mattola; Lari Pyöriä; Mari Toppinen; Jianming Qiu; Maija Vihinen-Ranta; Klaus Hedman; Johanna Nokso-Koivisto; Leena-Maija Aaltonen; Maria Söderlund-Venermo

doi:10.1128/mBio.03132-20

mBio (Feb 2021)

Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

Man Xu,
Maria Fernanda Perdomo,
Salla Mattola,
Lari Pyöriä,
Mari Toppinen,
Jianming Qiu,
Maija Vihinen-Ranta,
Klaus Hedman,
Johanna Nokso-Koivisto,
Leena-Maija Aaltonen,
Maria Söderlund-Venermo

Affiliations

Man Xu: ORCiD; Department of Virology, University of Helsinki, Helsinki, Finland
Maria Fernanda Perdomo: ORCiD; Department of Virology, University of Helsinki, Helsinki, Finland
Salla Mattola: Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland
Lari Pyöriä: ORCiD; Department of Virology, University of Helsinki, Helsinki, Finland
Mari Toppinen: ORCiD; Department of Virology, University of Helsinki, Helsinki, Finland
Jianming Qiu: ORCiD; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
Maija Vihinen-Ranta: ORCiD; Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland
Klaus Hedman: ORCiD; Department of Virology, University of Helsinki, Helsinki, Finland
Johanna Nokso-Koivisto: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland
Leena-Maija Aaltonen: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland
Maria Söderlund-Venermo: ORCiD; Department of Virology, University of Helsinki, Helsinki, Finland

DOI: https://doi.org/10.1128/mBio.03132-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal