mBio
(Feb 2021)
Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection
Man Xu,
Maria Fernanda Perdomo,
Salla Mattola,
Lari Pyöriä,
Mari Toppinen,
Jianming Qiu,
Maija Vihinen-Ranta,
Klaus Hedman,
Johanna Nokso-Koivisto,
Leena-Maija Aaltonen,
Maria Söderlund-Venermo
Affiliations
Man Xu
ORCiD Department of Virology, University of Helsinki, Helsinki, Finland
Maria Fernanda Perdomo
ORCiD Department of Virology, University of Helsinki, Helsinki, Finland
Salla Mattola
Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland
Lari Pyöriä
ORCiD Department of Virology, University of Helsinki, Helsinki, Finland
Mari Toppinen
ORCiD Department of Virology, University of Helsinki, Helsinki, Finland
Jianming Qiu
ORCiD Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
Maija Vihinen-Ranta
ORCiD Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland
Klaus Hedman
ORCiD Department of Virology, University of Helsinki, Helsinki, Finland
Johanna Nokso-Koivisto
Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland
Leena-Maija Aaltonen
Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland
Maria Söderlund-Venermo
ORCiD Department of Virology, University of Helsinki, Helsinki, Finland
DOI
https://doi.org/10.1128/mBio.03132-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.
WeChat QR code
Close
