Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

Vasantha Basavalingappa; Santu Bera; Bin Xue; Ido Azuri; Yiming Tang; Kai Tao; Linda J. W. Shimon; Michael R. Sawaya; Sofiya Kolusheva; David S. Eisenberg; Leeor Kronik; Yi Cao; Guanghong Wei; Ehud Gazit

doi:10.1038/s41467-019-13250-x

Nature Communications (Nov 2019)

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

Vasantha Basavalingappa,
Santu Bera,
Bin Xue,
Ido Azuri,
Yiming Tang,
Kai Tao,
Linda J. W. Shimon,
Michael R. Sawaya,
Sofiya Kolusheva,
David S. Eisenberg,
Leeor Kronik,
Yi Cao,
Guanghong Wei,
Ehud Gazit

Affiliations

Vasantha Basavalingappa: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University
Santu Bera: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University
Bin Xue: Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Key Laboratory of Intelligent Optical Sensing and Manipulation, Ministry of Education, Department of Physics, Nanjing University
Ido Azuri: Department of Materials and Interfaces, Weizmann Institute of Science
Yiming Tang: Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE), Fudan University
Kai Tao: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University
Linda J. W. Shimon: Department of Chemical Research Support, Weizmann Institute of Science
Michael R. Sawaya: Howard Hughes Medical Institute, UCLA-DOE Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles
Sofiya Kolusheva: Ilse Katz Institute for Nanotechnology, Ben Gurion University of the Negev
David S. Eisenberg: Howard Hughes Medical Institute, UCLA-DOE Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles
Leeor Kronik: Department of Materials and Interfaces, Weizmann Institute of Science
Yi Cao: Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Key Laboratory of Intelligent Optical Sensing and Manipulation, Ministry of Education, Department of Physics, Nanjing University
Guanghong Wei: Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE), Fudan University
Ehud Gazit: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University

DOI: https://doi.org/10.1038/s41467-019-13250-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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DNA is an attractive nanomaterial, yet limited compared to polyamides due to low stability and mechanical issues. Here, the authors combine polyamide and DNA characteristics to form mechanically rigid self-assembled peptide nucleic acid based materials with high stiffness and Young’s modulus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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