Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticles

Abstract

In present study, we assessed the antitumor and antibacterial response of Zn0.5Co0.5Fe2O4 nanoparticles (NPs) synthesized usingsol-gel method. The toxicological mechanism of current smart materials is considered to be valuable keeping in view its many promising applications. The structure, morphology, and magnetic behavior of theZnxCo(1-x)Fe2O4 nanoparticles NPs were assessed using X-ray diffraction and scanning electron microscopy. The cytotoxic and photo-cytotoxic responses of the magnetic NPs were examined in a hepatocellular HepG2 model in the dark and under an optimum laser fluence dose of 80 J/cm2 using a wavelength of 630 nm for a short exposure time. A percentage loss of 60% was observed in a 250 µg/mL NP solution according to the cell viability of the labeled HepG2 cell model. Empirical modeling analysis revealed the reflex duplicate response of the experimental results. Antibacterial studies were performed on different types of bacteria via in vitro optical density analysis. Presented vision with varying factors will be useful for biomedical applications of Zn0.5Co0.5Fe2O4 nanoparticles. Keywords: Spinel ferrite, PDT, HepG2 model, NRA, Reactive oxygen species (ROS), Drug delivery, Sol-gel method, Bioactivity, Cell viability