Nature Communications (Apr 2021)
Skeletal muscle transcriptome in healthy aging
- Robert A. Tumasian,
- Abhinav Harish,
- Gautam Kundu,
- Jen-Hao Yang,
- Ceereena Ubaida-Mohien,
- Marta Gonzalez-Freire,
- Mary Kaileh,
- Linda M. Zukley,
- Chee W. Chia,
- Alexey Lyashkov,
- William H. Wood,
- Yulan Piao,
- Christopher Coletta,
- Jun Ding,
- Myriam Gorospe,
- Ranjan Sen,
- Supriyo De,
- Luigi Ferrucci
Affiliations
- Robert A. Tumasian
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Abhinav Harish
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Gautam Kundu
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Jen-Hao Yang
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Ceereena Ubaida-Mohien
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Marta Gonzalez-Freire
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Mary Kaileh
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Linda M. Zukley
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Chee W. Chia
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Alexey Lyashkov
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- William H. Wood
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Yulan Piao
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Christopher Coletta
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Jun Ding
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Myriam Gorospe
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Ranjan Sen
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Supriyo De
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- Luigi Ferrucci
- National Institute on Aging–Intramural Research Program, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-22168-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during aging in healthy individuals.
