Data correlations between gender, cytomegalovirus infection and T cells, NK cells, and soluble immune mediators in elderly humans
Ahmad Al-Attar,
Steven R. Presnell,
Charlotte A. Peterson,
D. Travis Thomas,
Charles T. Lutz
Affiliations
Ahmad Al-Attar
Department of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA
Steven R. Presnell
Department of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA
Charlotte A. Peterson
Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, KY, USA
D. Travis Thomas
Department of Clinical Sciences, College of Health Sciences, University of Kentucky, Lexington, KY, USA
Charles T. Lutz
Department of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA; Department of Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA; Corresponding author.
We describe a cohort of 50 elderly subjects, age at least 70 years. We present gender-specific findings in T lymphocyte markers and soluble immune mediators. We show the correlation between cytomegalovirus infection status with CD56dim NK cell responses to a variety of stimuli and with CD56bright/CD56dim NK cell ratio. We also present the correlation of retinol binding protein (RBP)−4 plasma levels with NK cell responses and we explore the relationship between gender and adiponectin, 25(OH)D (vitamin D), and RBP4 in affecting CD56dim NK cell responses. These data are discussed in Al-Attar et al. (2016) [1]. Keywords: NK cell, Ageing, Cytomegalovirus, T cell, Sex factors, Vitamin D, C-reactive protein, Adiponectin, IL-15, Sphingosine-1-phosphate, Retinol binding protein-4
