INVESTIGATION OF RELATION BETWEEN CODON 27 BETA-2 ADRENERGIC RECEPTOR POLYMORPHYSMS WITH BREAST CANCER

Abstract

Breast Cancer is a common cancer in the world with high mortality rates. Besides the environmental factors, genetic factors have an important role in etiology of breast cancer. Genetic factors are tumor supressor genes, protooncogenes and genetic polymorphysms. There are reports in literature that polymorphysms in Beta-2 Adrenergic Receptor (ADRB2) gene can be a risk factor for breast cancer. In our study; ADRB2 gene codon Gln27 􀃆 Glu polymorhpysm’s role in etiology of breast cancer is analysed in Mersin sample- Turkish population. 190 breast cancer patients are followed by Clinical Oncology Polyclinics in Mersin University Medical Faculty. 132 healty people with similar age and gender characteristics are followed in control group. Sample population is 322 people. Mean age is 50,7±8,6 in patient group and 48,5±8,5 in control group. In our study, ADRB2 gene codon 27 Gln27 􀃆Glu polymorhpysm does not appear to be a significant risk factor in etiology of breast. Being older than 60 years old, having a body mass index (BMI) greater than 25 and having familial breast cancer history appear to be a risk factor. Distributions of ADRB2 genotypes for breast cancer according to presumed risk factors: Glu/Gln and Glu/ Gln+Glu/Glu genotype in people younger than 50 years old, Glu/Gln, Glu/ Glu and Glu/Gln+Glu/Glu genotype in premenopausal age group and Glu/ Gln and Glu/Glu genotype in people who has menarchial age less than 13 have higher risk of having breast cancer.

Keywords

• breast cancer
• adrb2 gene
• polymorphism
• turkish population
• mersin sample.