Could the Spike Protein Derived from mRNA Vaccines Negatively Impact Beneficial Bacteria in the Gut?
Alberto Rubio-Casillas,
Mark Fabrowski,
Carlo Brogna,
David Cowley,
Elrashdy M. Redwan,
Vladimir N. Uversky
Affiliations
Alberto Rubio-Casillas
Autlan Regional Hospital, Jalisco Health Services, Autlan 48900, JAL, Mexico
Mark Fabrowski
Department of Emergency Medicine, Royal Sussex County Hospital, University Hospitals Sussex, Eastern Road, Brighton BN2 5BE, UK
Carlo Brogna
Department of Research, Craniomed Group Facility Srl., 20091 Bresso, Italy
David Cowley
Independent Researcher, Nottingham, UK
Elrashdy M. Redwan
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Vladimir N. Uversky
Department of Molecular Medicine, USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
The emergence of mRNA vaccines for SARS-CoV-2 has opened a new page in vaccine development. Nevertheless, concerns of experts have been expressed about unintentional side effects on the gut microbiota (GM). Previous studies showed that this virus acts as a bacteriophage, which infects and destroys specific bacterial strains in the GM. The present manuscript hypothesizes that the synthetic spike protein could create changes in the composition and the functioning of the GM by entering the intestinal cells after vaccination and impairing the symbiotic relationship between intestinal cells and the GM. An experimental protocol to test the hypothesis is suggested.
