P-116 AUTOIMMUNE DISEASES ASSOCIATED WITH AUTOIMMUNE HEPATITIS: EXPERIENCE IN TWO PARAGUAYAN CENTERS.

Abstract

Introduction and Objectives: Autoimmune hepatitis (AIH) occurs in patients with a personal or family history of other autoimmune diseases (AID). In Paraguay, there is no information regarding what these diseases are and how often these diseases are found in patients with AIH. This study aimed to determine which autoimmune diseases occur in first-degree families and in patients with HAI in Paraguay. Materials and Methods: Design: an observational longitudinal retrospective descriptive observational study. Patients from the Department of Gastroenterology of the Clinics Hospital and another outpatient reference center, with a diagnosis of AIH, according to the criteria of the Revised Original AIH Score, over 18 years of age, who consulted between January 2014 and December 2018, were included. Results: 77 patients; average age: 40±19. Female 83%; male 17%: Ratio 4.9/1. Twenty-two (29%) had a family history of AID: autoimmune hypothyroidism in 7 (32%); AIH in 4 (18%); rheumatoid arthritis (RA) in 4 (18%); Systemic lupus erythematosus (SLE) in 3 (14%); other AIDs in 4 (18%).Twenty-five (33%) patients had AIH-associated AID. These were: autoimmune hypothyroidism in 7 (28%); RA in 5 (20%); celiac disease in 3 (12%); inflammatory bowel disease in 2 (8%); autoimmune thrombocytopenic purpura in 2 (8%) and other AIDs in 6 (24%) Conclusions: As in series from other countries, patients with AIH frequently have an associated AID and/or family history of AID. As a family or personal history, autoimmune thyroid disease was the most frequently associated with AID.