Nature Communications (Apr 2021)
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
- Aarti Jagannath,
- Norbert Varga,
- Robert Dallmann,
- Gianpaolo Rando,
- Pauline Gosselin,
- Farid Ebrahimjee,
- Lewis Taylor,
- Dragos Mosneagu,
- Jakub Stefaniak,
- Steven Walsh,
- Teele Palumaa,
- Simona Di Pretoro,
- Harshmeena Sanghani,
- Zeinab Wakaf,
- Grant C. Churchill,
- Antony Galione,
- Stuart N. Peirson,
- Detlev Boison,
- Steven A. Brown,
- Russell G. Foster,
- Sridhar R. Vasudevan
Affiliations
- Aarti Jagannath
- Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, OMPI-G
- Norbert Varga
- Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, OMPI-G
- Robert Dallmann
- Biomedical Sciences, Warwick Medical School, University of Warwick
- Gianpaolo Rando
- Department of Molecular Biology, University of Geneva
- Pauline Gosselin
- Department of Molecular Biology, University of Geneva
- Farid Ebrahimjee
- Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford
- Lewis Taylor
- Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, OMPI-G
- Dragos Mosneagu
- Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford
- Jakub Stefaniak
- Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford
- Steven Walsh
- Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, OMPI-G
- Teele Palumaa
- Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, OMPI-G
- Simona Di Pretoro
- Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, OMPI-G
- Harshmeena Sanghani
- Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford
- Zeinab Wakaf
- Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford
- Grant C. Churchill
- Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford
- Antony Galione
- Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford
- Stuart N. Peirson
- Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, OMPI-G
- Detlev Boison
- Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University
- Steven A. Brown
- Institute of Pharmacology and Toxicology, University of Zurich
- Russell G. Foster
- Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, OMPI-G
- Sridhar R. Vasudevan
- Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-021-22179-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light, providing a molecular link between sleep pressure and circadian rhythm.
