Prognostic Values of LDH and CRP in Cervical Cancer

Abstract

Han Wang,1,* Meng-Sen Wang,2,* Yong-Heng Zhou,1,* Jian-Ping Shi,3 Wen-Jie Wang3 1Department of Oncology, Jining Cancer Hospital, Jining, Shandong, People’s Republic of China; 2Department of Oncology, Jining No. 1 People’s Hospital, Jining, Shandong, People’s Republic of China; 3Department of Radio-Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen-Jie WangDepartment of Radio-Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, People’s Republic of ChinaTel [phone]Fax [phone]Email [email protected]: Cervical cancer is one of the deadliest tumors among women in China. C-reactive protein (CRP), an indicator of inflammation, and lactate dehydrogenase (LDH), an enzyme ubiquitously expressed in cells, both play important roles in tumor growth and metastasis.Patients and Methods: Based on pre-radiotherapy LDH and CRP median levels, we divided patients into four groups: high LDH and CRP group, high LDH group, high CRP group, and low LDH and CRP group. Then, based on pre-/post-radiotherapy LDH and CRP ratios, we divided patients into four groups: high LDH and CRP ratio group, high LDH ratio group, high CRP ratio group, and low LDH and CRP ratio group. Kaplan–Meier (KM) curves were constructed to show overall survival (OS). A multivariate Cox regression model was employed to identify the independent risk factors.Results: High pre-radiotherapy LDH and CRP levels and increased pre-/post-radiotherapy LDH and CRP ratios were correlated with worst OS compared with the other three groups.Conclusion: LDH and CRP were correlated with outcomes in patients with locally advanced cervical cancer.Keywords: cervical cancer, LDH, CRP, prognosis, OS

Keywords

• cervical cancer
• ldh
• crp
• prognosis
• os