Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of <i>Albizia lebbeck</i> L. Benth (Fabaceae)

Bosco Peron Leutcha; Jean Paul Dzoyem; Jean-Bosco Jouda; Denis Kehdinga Sema; Virginie Flaure Tsague Tankeu; Gabin Thierry Mbahbou Bitchagno; Billy Toussie Tchegnitegni; Flaure Rosette Ehawa Essoung; Bruno Ndjakou Lenta; Siméon Fogue Kouam; Florence Delie; Alain Meli Lannang; Norbert Sewald

doi:10.3390/molecules27154823

Molecules (Jul 2022)

Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of <i>Albizia lebbeck</i> L. Benth (Fabaceae)

Bosco Peron Leutcha,
Jean Paul Dzoyem,
Jean-Bosco Jouda,
Denis Kehdinga Sema,
Virginie Flaure Tsague Tankeu,
Gabin Thierry Mbahbou Bitchagno,
Billy Toussie Tchegnitegni,
Flaure Rosette Ehawa Essoung,
Bruno Ndjakou Lenta,
Siméon Fogue Kouam,
Florence Delie,
Alain Meli Lannang,
Norbert Sewald

Affiliations

Bosco Peron Leutcha: Department of Chemistry, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Jean Paul Dzoyem: Department of Biochemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
Jean-Bosco Jouda: Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Ngaoundéré P.O. Box 454, Cameroon
Denis Kehdinga Sema: Department of Chemistry, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Virginie Flaure Tsague Tankeu: Department of Chemistry, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Gabin Thierry Mbahbou Bitchagno: Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
Billy Toussie Tchegnitegni: Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon
Flaure Rosette Ehawa Essoung: University Institute of Technology, University of Ngaoundere, Ngaoundere P.O. Box 455, Cameroon
Bruno Ndjakou Lenta: Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon
Siméon Fogue Kouam: Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon
Florence Delie: Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland
Alain Meli Lannang: Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Ngaoundéré P.O. Box 454, Cameroon
Norbert Sewald: Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, 33501 Bielefeld, Germany

DOI: https://doi.org/10.3390/molecules27154823
Journal volume & issue: Vol. 27, no. 15
p. 4823

Abstract

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Twenty-two compounds were isolated from the fruit of Albizia lebbeck including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed. Some isolated compounds were reported for the first time to be found in the species. Additionally, compound 2 showed antibacterial activity and compounds 1 and 2 revealed moderate cytotoxic activity against the Raw 264.7 cancer cell line with IC50 values of 37.19 µM and 29.36 µM, respectively. Furthermore, a proposed biosynthetic pathway of compound 1 is described.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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