Nature Communications (Feb 2020)

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

  • Jacob Paiano,
  • Wei Wu,
  • Shintaro Yamada,
  • Nicholas Sciascia,
  • Elsa Callen,
  • Ana Paola Cotrim,
  • Rajashree A. Deshpande,
  • Yaakov Maman,
  • Amanda Day,
  • Tanya T. Paull,
  • André Nussenzweig

DOI
https://doi.org/10.1038/s41467-020-14654-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that the ATM kinase governs the release of SPO11.