Communications Biology (Aug 2021)

Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

  • Tudor Petreus,
  • Elaine Cadogan,
  • Gareth Hughes,
  • Aaron Smith,
  • Venkatesh Pilla Reddy,
  • Alan Lau,
  • Mark James O’Connor,
  • Susan Critchlow,
  • Marianne Ashford,
  • Lenka Oplustil O’Connor

DOI
https://doi.org/10.1038/s42003-021-02526-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically. They test colorectal cancer spheroids with combinations of two drugs and show that it can successfully predict efficacy in vivo, thereby providing a valuable tool for drug response and pharmacodynamic assessment and reducing the need for animal studies.