Case of Carbapenem-Resistant Salmonella Typhi Infection, Pakistan, 2022

Abstract

Salmonella Typhi infection in a patient in Pakistan initially responded to standard treatment but failed to respond to subsequent treatment. The first strain was susceptible to carbapenems and azithromycin; subsequent strains harbored the NDM-5 gene. Treatment with a combination of intravenous meropenem and colistin was successful. Carbapenem-resistant Salmonella Typhi emergence will hinder treatment.

Keywords

• Salmonella Typhi
• Salmonella enteria serovar Typhi
• therapy
• diagnosis
• antimicrobial resistance
• carbapenem resistance