Nature Communications (Dec 2021)
The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer
- Neha Singh,
- Varune R. Ramnarine,
- Jin H. Song,
- Ritu Pandey,
- Sathish K. R. Padi,
- Mannan Nouri,
- Virginie Olive,
- Maxim Kobelev,
- Koichi Okumura,
- David McCarthy,
- Michelle M. Hanna,
- Piali Mukherjee,
- Belinda Sun,
- Benjamin R. Lee,
- J. Brandon Parker,
- Debabrata Chakravarti,
- Noel A. Warfel,
- Muhan Zhou,
- Jeremiah J. Bearss,
- Ewan A. Gibb,
- Mohammed Alshalalfa,
- R. Jefferey Karnes,
- Eric J. Small,
- Rahul Aggarwal,
- Felix Feng,
- Yuzhuo Wang,
- Ralph Buttyan,
- Amina Zoubeidi,
- Mark Rubin,
- Martin Gleave,
- Frank J. Slack,
- Elai Davicioni,
- Himisha Beltran,
- Colin Collins,
- Andrew S. Kraft
Affiliations
- Neha Singh
- University of Arizona Cancer Center, University of Arizona
- Varune R. Ramnarine
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia
- Jin H. Song
- University of Arizona Cancer Center, University of Arizona
- Ritu Pandey
- University of Arizona Cancer Center, University of Arizona
- Sathish K. R. Padi
- University of Arizona Cancer Center, University of Arizona
- Mannan Nouri
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia
- Virginie Olive
- University of Arizona Cancer Center, University of Arizona
- Maxim Kobelev
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia
- Koichi Okumura
- University of Arizona Cancer Center, University of Arizona
- David McCarthy
- Ribomed Biotechnologies, Inc., 8821N. 7th St. STE 300
- Michelle M. Hanna
- Ribomed Biotechnologies, Inc., 8821N. 7th St. STE 300
- Piali Mukherjee
- Epigenomics Core Facility, Weill Cornell Medicine
- Belinda Sun
- Department of Cellular and Molecular Medicine, University of Arizona
- Benjamin R. Lee
- University of Arizona Cancer Center, University of Arizona
- J. Brandon Parker
- Department of Obstetrics and Gynecology, Division of Reproductive Science in Medicine, Feinberg School of Medicine, Northwestern University
- Debabrata Chakravarti
- Department of Obstetrics and Gynecology, Division of Reproductive Science in Medicine, Feinberg School of Medicine, Northwestern University
- Noel A. Warfel
- University of Arizona Cancer Center, University of Arizona
- Muhan Zhou
- University of Arizona Cancer Center, University of Arizona
- Jeremiah J. Bearss
- University of Arizona Cancer Center, University of Arizona
- Ewan A. Gibb
- Decipher Biosciences, Inc
- Mohammed Alshalalfa
- Department of Radiation Oncology, University of California San Francisco
- R. Jefferey Karnes
- Department of Urology, Mayo Clinic College of Medicine
- Eric J. Small
- Department of Radiation Oncology, University of California San Francisco
- Rahul Aggarwal
- Department of Radiation Oncology, University of California San Francisco
- Felix Feng
- Department of Radiation Oncology, University of California San Francisco
- Yuzhuo Wang
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia
- Ralph Buttyan
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia
- Amina Zoubeidi
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia
- Mark Rubin
- Department for BioMedical Research, University of Bern
- Martin Gleave
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia
- Frank J. Slack
- Harvard Medical School Initiative for RNA Medicine, Harvard Medical School
- Elai Davicioni
- Decipher Biosciences, Inc
- Himisha Beltran
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Colin Collins
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia
- Andrew S. Kraft
- University of Arizona Cancer Center, University of Arizona
- DOI
- https://doi.org/10.1038/s41467-021-26901-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Elevated expression of long noncoding RNA H19 is seen in clinical samples of neuroendocrine prostate cancer (PCa). Here the authors show H19 promotes plasticity from luminal to neuroendocrine by epigenetic reprogramming.
