Frontiers in Immunology (Feb 2022)
Case Report: Cerebral Nocardiosis Caused by Nocardia cyriacigeorgica Detected by Metagenomics in an Apparently Immunocompetent Patient
- Virginie Courbin,
- Quentin Riller,
- Jean-Louis Amegnizin,
- Guillaume Gricourt,
- Vanessa Demontant,
- Vincent Fihman,
- Vincent Fihman,
- Cecile Angebault,
- Cecile Angebault,
- Matthieu Mahevas,
- Géraldine Gaube,
- Laëtitia Coutte,
- Jean-Michel Pawlotsky,
- Jean-Michel Pawlotsky,
- Raphaël Lepeule,
- Christophe Rodriguez,
- Christophe Rodriguez,
- Paul-Louis Woerther,
- Paul-Louis Woerther,
- Paul-Louis Woerther
Affiliations
- Virginie Courbin
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Quentin Riller
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Jean-Louis Amegnizin
- Department of Radiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Guillaume Gricourt
- NGS Plateform, IMRB Institute, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Vanessa Demontant
- NGS Plateform, IMRB Institute, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Vincent Fihman
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Vincent Fihman
- EA Dynamyc 7380, Université Paris Est Créteil-Ecole nationale Vétérinaire de Maisons-Alfort, Créteil, France
- Cecile Angebault
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Cecile Angebault
- EA Dynamyc 7380, Université Paris Est Créteil-Ecole nationale Vétérinaire de Maisons-Alfort, Créteil, France
- Matthieu Mahevas
- Internal Medicine Department, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Géraldine Gaube
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Laëtitia Coutte
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Jean-Michel Pawlotsky
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Jean-Michel Pawlotsky
- NGS Plateform, IMRB Institute, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Raphaël Lepeule
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Christophe Rodriguez
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Christophe Rodriguez
- NGS Plateform, IMRB Institute, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Paul-Louis Woerther
- Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Paul-Louis Woerther
- NGS Plateform, IMRB Institute, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France
- Paul-Louis Woerther
- EA Dynamyc 7380, Université Paris Est Créteil-Ecole nationale Vétérinaire de Maisons-Alfort, Créteil, France
- DOI
- https://doi.org/10.3389/fimmu.2022.719124
- Journal volume & issue
-
Vol. 13
Abstract
We report a case of meningoencephalitis due to Nocardia cyriacigeorgica diagnosed with metagenomics, while all the standard methods were negative. This diagnosis made adaptation of antimicrobial treatment possible and led to the discovery of a rare, acquired immunodeficiency syndrome.
Keywords
