Nature Communications (Nov 2019)
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
- Jayaram Vijayakrishnan,
- Maoxiang Qian,
- James B. Studd,
- Wenjian Yang,
- Ben Kinnersley,
- Philip J. Law,
- Peter Broderick,
- Elizabeth A. Raetz,
- James Allan,
- Ching-Hon Pui,
- Ajay Vora,
- William E. Evans,
- Anthony Moorman,
- Allen Yeoh,
- Wentao Yang,
- Chunliang Li,
- Claus R. Bartram,
- Charles G. Mullighan,
- Martin Zimmerman,
- Stephen P. Hunger,
- Martin Schrappe,
- Mary V. Relling,
- Martin Stanulla,
- Mignon L. Loh,
- Richard S. Houlston,
- Jun J. Yang
Affiliations
- Jayaram Vijayakrishnan
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Maoxiang Qian
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- James B. Studd
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Wenjian Yang
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- Ben Kinnersley
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Philip J. Law
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Peter Broderick
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Elizabeth A. Raetz
- Division of Pediatric Hematology and Oncology, New York University Langone Health
- James Allan
- Northern Institute for Cancer Research, Newcastle University
- Ching-Hon Pui
- Department of Oncology, St. Jude Children’s Research Hospital
- Ajay Vora
- Great Ormond Hospital
- William E. Evans
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- Anthony Moorman
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Allen Yeoh
- Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- Wentao Yang
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- Chunliang Li
- Department of Tumor Cell Biology, St. Jude Children’s Research Hospital
- Claus R. Bartram
- Institute of Human Genetics, University Hospital
- Charles G. Mullighan
- Department of Oncology, St. Jude Children’s Research Hospital
- Martin Zimmerman
- Department of Paediatric Haematology and Oncology, Hannover Medical School
- Stephen P. Hunger
- Department of Paediatrics and Centre for Childhood Cancer Research, Children’s Hospital of Philadelphia and the Perelman School of Medicine at The University of Pennsylvania
- Martin Schrappe
- Department of Paediatrics, University Medical Centre Schleswig-Holstein
- Mary V. Relling
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- Martin Stanulla
- Department of Paediatric Haematology and Oncology, Hannover Medical School
- Mignon L. Loh
- Department of Pediatrics, Benioff Children’s Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Jun J. Yang
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/s41467-019-13069-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion.
